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Design,Synthesis and Biological Evaluation of the Novel Poly (ADP-ribose) Polymerase-1 (PARP-1) Inhi
[会议论文] 作者：Qihua Zhu,Xuyang Wang,Yungen Xu,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Poly (ADP-ribose) polymerase-1(PARP-1) is a nuclear enzyme involved in the detection and repair of DNA damage.Early studies identified nicotinamide(1a) as the PARP-1 inhibitor[1].Recently,the studies...
[会议论文] 作者：Qihua Zhu,Xueyan Wang,Yan Hu,Yungen Xu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Poly(ADP-ribose)polymerase-1(PARP-1)is a nuclear enzyme involved in the detection and repair of DNA damage.The inhibition of PARP-1 has several potential therapeutic applications for drug discovery.In...
Design, synthesis and preliminary biological evaluation of novel inhibitors of smoothened (SMO) rece
[会议论文] 作者：Dezhong Ji,Shuping Wang,Tingting Liang,Yungen Xu,
来源：2016年长三角药物化学研讨会 年份：2016
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Design and Synthesis of Tetrahydroisoquinoline Derivatives as Peripherally κ-Opioid Receptor Agonist
[会议论文] 作者：Zongjie Gan,Jie Chen,Jinggen Liu,Yungen Xu,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Over the past decades,considerable attention had been focused on the development of peripherally acting selective κ-opioid receptor agonists devoid of many side effects associated with μ-agonists and...
[会议论文] 作者：Qihua Zhu,Junwei Wang,Lingzhi Zhang,Yungen Xu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Lorcaserin was approved in June 2012 by the FDA for the treatment of obesity.1 Several methods for the synthesis of lorcaserin have been reported,but these methods are unsuitable for industrial-scale...
[会议论文] 作者：Hui Li,Guangchao He,Junwei Wang,Qihua Zhu,Yungen Xu,
来源：2016年长三角药物化学研讨会 年份：2016
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[会议论文] 作者：Dezhong Ji,Xin He,Yizhu Xu,Qihua Zhu,Zhibin Wang,Yungen Xu,
来源：中国化学会第十三届全国有机合成化学学术研讨会 年份：2016
Quinoline is an important scaffold in various natural products and synthetic compounds with wide applications in medicinal and materials chemistry.In the re...
Synthesis and pharmacological evaluation of limonin derivatives as analgesic and anti-inflammatory a
[会议论文] 作者：Chengshu Jia,Shaochi Wang,Xueqing Han,Yiwei Wang,Qihua Zhu,Yungen Xu,
来源：2016年长三角药物化学研讨会 年份：2016
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