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[期刊论文] 作者：Yuran Qiu,Yuanhao Wang,Zongtao Chai,Duan Ni,Xinyi Li,Jun Pu,Jie Chen,Jian Zhang,Shaoyong Lu,Chuan Lv,,
来源：药学学报（英文版） 年份：2021
RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for～19％of th......
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migrati
[期刊论文] 作者：Zhimin Huang,Jiacheng Wei,Li Feng,Jun-Cheng Su,Yingqing Wei,Shaobo Ning,Xiuyan Yang,Mingzhu Zhao,Yuran Qiu,
来源：药学学报（英文版） 年份：2022
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the ......
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