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[期刊论文] 作者：ZHANG Lihe,ZHANG Kunyu,,
来源：Chinese Journal of Electronics 年份：2014
In the discriminative sparse coding,the reconstruction residual over each class-specific subdictionary can provide great discriminative and label information. In this paper, we propose a weighted disc...
[期刊论文] 作者：YANG Cheng,ZHANG Lihe,WANG Yon,
来源：武汉大学学报：自然科学英文版 年份：2006
在活动生意，目前，在用户的终端的安全环境没被嵌入，许多基于隐语的方法不能直接被用来保护数字媒介的版权。在这种状况下面，一个透明系统基于为数字正确管理的水位标；数字版权保护......
Advance on the synthesis and structure-activity relationships of 1-〔(2-hydroxy)methy〕-6-(phenylthio)
[期刊论文] 作者：Zhang Minglong,Ma Lingtai,Zhang Lihe,
来源：中国药物化学杂志 年份：1999
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[期刊论文] 作者：Tian Xiaobing,Zhang Lihe,Min Jimei,
来源：中国药学(英文版) 年份：2001
The chemistry of nucleosides and oligonucleotides is an actively investigated field in the search for new drugs. Thesyntheses and the properties of isonucleosi...
[期刊论文] 作者：Qin Zhihui,Zhang Lihe,LI Zhongjun,
来源：中国药学(英文版) 年份：2001
Selectins are a new class of carbohydrate-binding glycoproteins which have been identified on the surface of specific cell types, such as leukocytes, platelets...
Comparative Analysis of Pharmacophore Features and Quantitative Structure-Activity Relationships for
[会议论文] 作者：Shuang Zhang,Xiwen Xue,Liangren Zhang,Lihe Zhang,Zhenming Liu,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
Human CD38 is a member of ADP-ribosyl cyclase family,which is a type Ⅱor type Ⅲ transmembrane glycoprotein1.CD38 can catalyzes the transformation of β-NAD+and NADP to the Ca2+-mobilizing messengers cA...
Discovery and Identification of Agonists of Cyclic ADP-ribose Regulated Calcium Pathway Discovery an
[会议论文] 作者：Xuan Wang,Shuang Zhang,Hongwei Jin,Zhenming Liu,Liangren Zhang,Lihe Zhang,
来源：第八届国际分子模拟与信息技术应用学术会议 年份：2016
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[会议论文] 作者：Dongying Wu,Kai Yiu Ting,Liangren Zhang,Lihe Zhang,Hon Cheung Lee,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Human CD38 is a dual-functional protein that acts not only as a receptor but also as a signaling enzyme,catalyzing the formation of Ca2+ messenger molecules,cyclic ADP-ribose(cADPR),ADPR and nicotinic...
Alkylation of phosphorothioated thrombin binding aptamer improves the selectivity of inhibiting tumo
[会议论文] 作者：Yang Xiantao,Zhu Yuejie,Wang Chao,Guan Zhu,Zhang Lihe,Zhenjun Yang,
来源：中国化学会第十届全国化学生物学学术会议 年份：2017
Aptamers are recently extensively researched for therapy and diagnostic,thrombin binding aptamer is a 15nt deoxyribonucleic acid screened by SELEX that specifically binds to thrombin and inhibits bloo...
Discovery and Identification of Agonists of Cyclic ADP-ribose Regulated Calcium Pathway Discovery an
[会议论文] 作者：Xuan Wang,Shuang Zhang,Hongwei Jin,Zhenming Liu,Liangren Zhang,Lihe Zhang,
来源：第八届国际分子模拟与信息技术应用学术会议 年份：2016
Cyclic adenosine diphosphate ribose(cADPR) is a second messenger in the calcium signaling pathway.For elucidating its molecular mechanism to regulate calcium release,a lot of cADPR analogues have been...
[会议论文] 作者：YiyunPeng,Fei Yu,Qi Wang,Sulong Xiao,YongxiangZheng,Chuanling Zhang,Lihe Zhang,Demin Zhou,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Hepatitis C virus(HCV) is a leading cause of several liver problems,such as chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma1.An estimated 3.2million individuals in the United States and...
[期刊论文] 作者：WANG XiaoFeng,HUANG Ye,LIU Yang,CHEN Yue,JIN HongWei,ZHENG Yi,DU Quan,YANG ZhenJun,ZHANG LiHe,,
来源：Science China(Chemistry) 年份：2013
In this paper,a series of peptide-siRNA conjugates with phosphodiester unit as the linker targeting to Cdc2 gene were synthesized by solid phase stepwise strate...
[会议论文] 作者：Sulong Xiao,Demin Zhou,Qi Wang,Fei Yu,Yiyun Peng,Ming Yang,Matthieu Sollogoub,Pierre Sina(y),Yongmin Zhang,Lihe,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
Hepatitis C virus(HCV) is the leading cause of liver fibrosis and cirrhosis which eventually worsen to liver cancer.There is urgent need to improve anti-HCV therapies and discover novel therapeutic ap...
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