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Modulating balance of synaptic and extrasynaptic NMDA receptors as strategy for Alzheimer disease dr
[期刊论文] 作者：ZHOU Wen-xia,
来源：中国药理学与毒理学杂志 年份：2019
The unbalance between synaptic(Glu N2 A, mediating the protective pathway) and extrasynaptic NMDA receptors(NMDARs)(Glu N2 B, mediating the excitotoxic pathway)...
Modulating balance of synaptic and extrasynaptic NMDA receptors as strategy for Alzheimer disease dr
[会议论文] 作者：ZHOU Wen-xia,
来源：2019全国老年痴呆与认知障碍相关疾病学术大会 年份：2019
The unbalance between synaptic(GluN2A,mediating the protective pathway)and extra-synaptic NMDA receptors(NMDARs)(GluN2B,mediating the excitotoxic pathway)ha...
CA-30,an active fraction derived from Liuwei Dihuang Decoction,ameliorates cognitive deterioration v
[期刊论文] 作者：ZHOU Wen-xia,WANG Jian-hui,LEI,
来源：中国药理学与毒理学杂志 年份：2019
Alzheimer disease(AD)is the leading cause of dementia that affects millions of elderly people worldwide.The currently available therapies have limited efficacy....
LW-AFC,a new traditional Chinese medicine formula,shows promising therapeutic effects on Alzheimer d
[期刊论文] 作者：ZHOU Wen-xia,WANG Jian-hui,CHE,
来源：中国药理学与毒理学杂志 年份：2017
Alzheimer disease(AD) is the leading cause of dementia that affects millions of elderly people worldwide.The currently available therapies have limited efficacy...
S1A-5 Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects Aga
[期刊论文] 作者：ZHOU Wen-xia,HUANG Yan,SHEN We,
来源：神经药理学报 年份：2018
The unbalance between synaptic(GluN2A,mediating the protective pathway)and extrasynaptic NMDA receptors(NMDARs)(GluN2B,mediating the excitotoxic pathway)has bee...
Induced pluripotent stem cells-derived human microglia-like cells to study pathological changes of A
[期刊论文] 作者：XU Mei,JIANG Ning,ZHOU Wen-xia,
来源：中国药理学与毒理学杂志 年份：2018
OBJECTIVE To establish an in vitro cell model based on patient-specific human microglia to study the pathological mechanism of Alzheimer disease (AD) and to scr...
Liuwei Dihuang-active fraction combination,LW-AFC,improved spatial learning and memory impairment in
[会议论文] 作者：GUO Yan-fei,XIAO Zhi-yong,ZHOU Wen-xia,ZHANG Yong-xiang,
来源：2019全国老年痴呆与认知障碍相关疾病学术大会 年份：2019
OBJECTIVE Tumor necrosis factor-α(TNF-α)plays a vital role in cognitive dysfunction caused by stress.In our previous study,Liuwei Dihuang-active fraction combination(LW-AFC)could attenuate the effects...
Modulating balance of synaptic and extrasynaptic NMDA receptors(NMDARs)shows priority over nonselect
[会议论文] 作者：HUANG Yan,SHEN Wei,LIU Gang,ZHOU Wen-xia,ZHANG Yong-xiang,
来源：第十七届全国神经精神药理学学术会议 年份：2016
OBJECTIVE Alzheimer disease(AD)patients suffer a disturbance in the balance between synaptic NMDARs(NR2A,mediating the protective pathway)and extrasynaptic NMDARs(NR2B,mediating the excitotoxic pathwa...
Active fraction combination from Liuwei Dihuang decoction improves adult hippocampal neurogenesis an
[期刊论文] 作者：WEI Ming-xiao,FENG Shu-fang,SHI Tian-yao,ZHOU Wen-xia,ZHANG Yong-xiang,
来源：中国药理学与毒理学杂志 年份：2021
OBJECTIVE Cranial radiotherapy is clinically used in the treatment of brain tumors;however,the consequent cognitive and emotional dysfunctions seriously impair the life quality of patients.LW-AFC,an active fraction combination extracted fro......
[期刊论文] 作者：CHENG Xiao-Rui,QI Chun-Hui,WANG Tong-Xing,ZHOU Wen-Xia,ZHANG Yong-Xiang,
来源：中国天然药物 年份：2019
Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modem medicine.We provide a comprehens......
[会议论文] 作者：HUANG Yan,LI Dong,CHENG Bin,LIU Gang,ZHANG Yong-xiang,ZHOU Wen-xia,
来源：2019全国老年痴呆与认知障碍相关疾病学术大会 年份：2019
Liuwei Dihuang decoction(LW),a classic formula in traditional Chinese medicine(TCM),has been used for nearly one thousand years for various diseases with characteristic features of kidney yin deficien...
Corticosterone induced D-serine release deficit play an important role in long-term potentiation imp
[期刊论文] 作者：HUANG Yan,WANG Chen,YU Qi,LI Dong,SUN Na,ZHANG Yong-xiang,ZHOU Wen-xia,
来源：中国药理学与毒理学杂志 年份：2021
OBJECTIVE Previous studies showed that over activation of NMDA receptors may be a crucial cause of long-term potentiation(LTP)and cognitive impairment induced by stress or corticosterone.However,other studies showed that the function of NMD......
The selective BACE1 inhibitor Vla reduces Aβ production and ameliorates behavioral deficits in a mou
[会议论文] 作者：Xiao-rui CHENG,Yu ZHOU,Wei GU,Ai-hua NIE,Jun-ping CHENG,Jin-wu ZHOU,Wen-xia ZHOU,Yong-xiang ZHANG,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
...
The selective BACE1 inhibitor Vla reduces Aβ production and ameliorates behavioral deficits in a mou
[会议论文] 作者：Xiao-rui CHENG,Yu ZHOU,Wei GU,Ai-hua NIE,Jun-ping CHENG,Jin-wu ZHOU,Wen-xia ZHOU,Yong-xiang ZHANG,
来源：The 12th Meeting of the Asia Pacific Federation of Pharmacol 年份：2013
Aim: We are pursuing potent BACE1 inhibitors in an effort to identify suitable AD drug candidates.Methods: Employing a homogeneous, time-resolved fluorescence (hTRF) technique, we determined the selec...
[期刊论文] 作者：ZHANG Wen,SONG Jun-Ke,ZHANG Xue,ZHOU Qi-Meng,HE Guo-Rong,XU Xiao-Na,Yan Rong,ZHOU Wen-Xia,DU Guan-Hua,
来源：中国天然药物 年份：2018
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge,a traditional Chinese medicine,which has been used for the treatment of cerebrovascular diseases for centuries.The present study aimed to determi......
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