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Role of the C9ORF72 Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis and Frontotemporal Dem
[期刊论文] 作者：Zongbing Hao,Rui Wang,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2020
Since the discovery of the C9ORF72 gene in 2011,great advances have been achieved in its genetics and in identifying its role in disease models and pathological...
[期刊论文] 作者：Dan Wu,Zongbing Hao,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2018
Autophagy is an evolutionarily-conserved self-degradative process that maintains cellular homeostasis by eliminating protein aggregates and damaged organelles.Recently,vesicle-associated membrane protein-associated protein B (VAPB),which is......
Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/ Frontotemporal Dementia Causes Neurotoxici
[期刊论文] 作者：Rui Wang,Xingyun Xu,Zongbing Hao,Shun Zhang,Dan Wu,Hongyang Sun,Chenchen Mu,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2019
GGGGCC repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FrD).It has been reported that hexanucleotide repeat expansions in C9ORF72 produce five dipeptide rep......
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