ANALOGS相关论文
BPA, a widely-studied environmental endocrine disruptor, has been identified to affect cardiac differentiation and produ......
Aim: Based on the molecular and resistance mechanism of alkylating agent temozolomide (TMZ), TMZ analogss mechanism of a......
Synthesis and structure activity relationships of the simplified saframycin-ecteinascidin skeleton p
Bistetrahydroisoquinoline is a large family of natural products that display a range of biological properties such as an......
The tunable bandgap from 0.3 eV to 2 eV of black phosphorus(BP)makes it to fill the gap in graphene.When studying the pr......
Extracts of Gentianaceae herbs have been widely used as food additives, teas, or medicinal remedies for various human di......
An analog of phthalascidin (Pt-650) was synthesized with an improved synthetic route. With precursor 2 as the starting m......
Quantification of hepatitis B surface antigen(HBsAg)has been suggested to be helpful in the management of chronic hepati......
AIM: To describe a population of outpatients in Chinainfected by hepatitis B virus(HBV) and/or hepatitis C virus(HCV), a......
Chronic hepatitis C is a public health problem worldwide.Unfortunately,not all patients may benefit from antiviral thera......
<正> Whether sleep is brought on by sleep-inducing substances accumulated naturally in the brain is a question that has ......
<正> Schizandrin C (Wuweizisu C) is a new component isolated from Schizandra chinensis Baill in our Institute. Pharmacol......
Sequence and modified group analysis on C-terminal modified analogs of endomorphin-2 using electrosp
In this paper, a series of C-terminal modified analogs of endomorphin-2 is investigated using ESI-FT-ICR-MS. Some b, y″......
Synthesis and Characterization of 8-Chloro-7-(4-(3-chloropropanoyl)piperazin-1-yl)-1-cyclopropyl-6-f
A new compound 8-chloro-7-(4-(3-chloropropanoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carb......
5月3日,成都新朝阳作物科学有限公司的一项专利“Preparation method,agricultural composition and applications of natural Bra......
Design and synthesis of novel coumarin analogs and their nematicidal activity against five phytonema
The presence of hydroxyl groups at the C4 and C7 positions in coumarin backbone has been proposed as a potential modific......
Design,synthesis and biological activity of novel substituted pyrazole amide derivatives targeting E
In order to discover highly active ecdysone analogs, a series of new substituted pyrazole amide derivatives were obtaine......
Synthesis, bioactivity and functional evaluation of linker-modified allatostatin analogs as potentia
Insect growth regulators play an important role in integrated pest management strategies.The FGLa–allatostatins(ASTs)ar......
A series of novel daphneolone analogs was designed and synthesized on the basis of natural product 1,5-diphenyl-2-penten......
We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of(bromo......
Promising Ultraviolet Absorbers——Novel Guanine Analogs Having Significantly Improved Ultraviolet Abs
Structural properties of nucleobase underlie their ultrafast excited-state dynamics and low fluorescence quantum yields,......
A new series of bis-benzimidazole derivatives were designed and synthesized.In vitro cytotoxicity evaluation showed that......
Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and ......
Two monocarbonyl analogs of curcumin containing bis(2,6-difluorobenzyl) were synthesized,and their molecular structures ......
A series of l-oxacephem analogs were synthesized and their antibacterial properties against five strains of Gram-positiv......
Final adult height of girls with central precocious puberty or early and fast puberty could be impro
Objective To assess the efficacy and impact factors of treatment with Gonadotropin-releasing hormone analogs(GnRHa) in c......
Zinc(Ⅱ) coordination architectures based on 5-(1H-tetrazol-1-yl)-isophthalic acid:Synthesis,structur
With different pyridine-analogs as auxiliary ligands,three novel Zn(Ⅱ) complexes(1-3) based on 5-(1Htetrazol-1-yl) isop......
An efficient method for the synthesis of benzo[b]benzofurano[2,3-e][1,6]naphthyridine-8-one derivatives has been develop......
A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE(P_S~1-cIDPRE) was d......
A rapid, simple and selective method based on molecularly imprinted, spin column extraction coupled with fluorescence de......
In search of novel anticancer agents,a series of thalidomide analogs(6a-j)were designed and synthesized.Cytotoxicity of ......
Syntheses and Crystal Structures of Two New α-Aminophosphonate Derivatives Containing Thieno[2,3-d]p
Two new α-aminophosphonate derivatives containing thieno[2,3-d]pyrimidine, diethyl(((6-ethyl-2-methyl-4-oxothieno[2,3-d......
Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterp......
Characterization and quantitation of aristolochic acid analogs in different parts of Aristolochiae F
Aristolochiae Fructus, a Chinese herbal medicine derived from the fruit of Aristolochia contorta Bge., contains nephroto......
An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl-1,2,3,4-tetrahydroi......
Study on radiolabeling of 1,2,3-triazole analogs with fac-[~(188)Re(CO)_3 (H_2O)_3 ]~+ via click che
Click chemistry was used to study on radiolabeling of 1,2,3-triazole analogs with fac-[188 Re(CO) 3 (H 2 O) 3]+ . CuSO 4......
The present work reports the first solid phase synthesis of biologically interesting D-threo-1-phenyl-2-decanoylamino-3-......
Three new nicotinamide adenine dinucleotide(NAD) analogs were synthesized,and their characteristics as cofactors for Esc......
A series of 5’-phenyl-3’H-spiro[indoline-3,2’-[1,3,4]thiadiazol]-2-one analogs were synthesized and their Bcl-2 prote......
Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling stu
Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease in......
Synthesis and biological evaluation of substituted indazolyl amide derivatives as S-adenosyl-L-homoc
A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S-adeno......
A novel and efficient strategy involving a CuI catalyzed cascade reaction to synthesize acenaphtho[1
A novel and efficient approach for the straightforward synthesis of biologically significant acenaphtho[1,2-b]quinoline ......
Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone an
In view of potent antimicrobial and anti-inflammatory activities exhibited by 5-substituted imidazolones, a variety of n......
In order to investigate the effects on the cytotoxicity of indole-3-oxalylamino podophyllotoxin analogs, seven novel pod......
Benzoxaborole,as a versatile scaffold,plays important roles in organic synthesis,molecular recognition and supramolecula......
Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
A series of pyrrolo[1,2-a]pyrazinone compounds(5a-9f) were synthesized,and their cytotoxic activity against SKOV-3,A549.......
Polymer chain architectures play a crucial role in the physical properties of polymers and this unique phenomenon has be......
Oxidative intramolecular coupling of 2,3-disubstituted phenyl acrylic acids and derivatives promoted
Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of ty......
We have previously found that several families of nonpolar short chain 11 β-ethers and esters of estradiol are selectiv......
Discovery and synthesis of N~2,N~4-substitued-cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first
A series of novel, cycloalkyl-modified pazopanib analogs 2 and 3 were designed and synthesized. Their kinase modulatory ......
Spiro heterocycles frequently occur in bioactive molecules.In the pursuit of neonicotinoids with spiro heterocycles,thre......
