Using RIP-Chip (RNA Immunoprecipitation Applied to Microarrays) to Discover Coordinate Posttranscrip

来源 :2011第四届世界癌症大会暨乳腺癌峰会 | 被引量 : 0次 | 上传用户:A123_1
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  Due to the poor correlation between steady state mRNA levels and protein products, traditional microarray analysis may miss genes which are regulated primarily at the level of mRNA stability and translation.Posttranscriptional gene regulation is becoming increasingly recognized as an important form of cellular control and the importance of microRNAs and RNA binding proteins (RBPs) is now beginning to be better appreciated.We study the elav (embryonic lethal abnormal vision) family of RBPs, which are paraneoplastic antigens, over-expressed in a variety of malignancies, including breast cancer.
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