Tumor metastasis is the major cause of treatment failure in mammary cancer.Steroid receptor co-activator-3 (SRC-3) plays important roles in tumorigenesis and participated in the stage of breast cancer and contributes to invasion and metastasis of tumors.However,the molecular mechanisms that mediate the role of SRC-3 in invasion and metastasis remains largely unknown.In our study,SRC-3 wild type cells exhibited strong metastasis and invasion capabilities,reduced E-cadherin epithelial marker,and gained N-cadherin mesenchymal marker.