Activation of dendritic cells in umbilical cord blood can improve the autologous NK cytotoxic activi

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户:liqiuru1025
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective In this study,we co-cultured the selected CD56+NK cells with activated mature DCs(include myeloid DCs and plasmacytoid DCs) from the autologous umbilical cord blood purposed to investigate their change of biological activity.Methods Umbilical cord blood samples were obtained from the donors(n=5).
其他文献
Background Chronic B lymphoproliferative diseases (BLPD),which are mainly compo sed of chronic lymphocytic leukemia (CLL),hairy cell leukemia (HCL),follicular lymphom a (FL),marginal zone lymphoma (MZ
会议
Background A recent GWAS analysis of B-cell chronic lymphocytic leukemia (CLL) identified 12 risk loci,some of which harbor apoptosis-related tumor suppressor genes.Herein we postulate that miR-3151,l
会议
Background The tumor suppressor TP53 is one of the most frequently altered genes in cancer.Several studies have shown TP53 mutations are frequently detected in patients with therapy-related AML or AML
会议
Introduction Donor cell neoplasms are rare complications of treatment regimens that involve stem cell transplantation for hematological malignancies,myelodysplastic processes,or certain genetic or met
会议
Background FLT3 mutation is found in about 30 %of acute myeloid leukemia (AML) patients and several FLT3 inhibitors are undergoing investigation,but clinical efficacies were lower than expected.In pre
会议
To clarify the prevalence and prognostic significance of c-KIT mutations in patients with core binding factor acute myeloid leukemia (CBF-AML),a total of 351 patients who were categorized into pediatr
会议
Background Recent studies has suggested that high levels of glycolytic metabolism in A ML blasts were associated with resistance to chemotherapy and pateintss survival.TP53-induced glycolysis and apop
会议
In cancer,defective differentiation is one of characteristics and targeted for therapy.Compared to general therapeutic strategies with cytotoxic compounds in cancer treatment,the differentiation thera
会议
Objective Umbilical cord blood (UCB) represents an alternative stem cell source for transplantation.UCB offers advantages over bone marrow or mobilized peripheral blood including ready availability,et
会议
Introduction In acute myeloid leukemia,FLT3 mutations are associated with a poor prognosis,particularly the internal tandem duplication.FLT3 is a tyrosine kinase receptor with an important role in sur
会议