【摘 要】
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One approach in the treatment of lung cancer that has generated interest in recent years is the use of novel drugs that selectively inhibit tumor blood supply, thus controlling cancer cell survival, p
【机 构】
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College of Pharmacy and Pharmaceutical Sciences Florida A&M University USA
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
One approach in the treatment of lung cancer that has generated interest in recent years is the use of novel drugs that selectively inhibit tumor blood supply, thus controlling cancer cell survival, proliferation and/or metastasis.The objective of this study was to formulate tumor homing PEGylated CREKA peptide conjugated nanoparticles of DIM-C-pPhC6H5 [DIM-P, PCNCs-D] and investigate in vivo antitumor activity as well as evaluate the targeted efficiency to lung tumors using imaging techniques like the use of IVIS(R) SpectrumCT (Caliper life Sciences) & Vevo(R) 2100 (VISUALSONICS).Particle size of PCNCs-D was found to be 190 ± 20 nm.PCNCs-D showed (p<0.001) 3 fold higher binding to clotted plasma proteins compared to NCs-D.Pharmacokinetic parameters showed that PCNCs-D increased plasma half-life of DIM-P from 0.83±0.26 hr to 3.23±0.23 hr.PCNCs-D showed 26±4% and 22±5% increase in tumor reduction compare to NCs-D in metastatic and orthotopic models respectively.DIM-P showed inhibition of VEGF and Sp proteins as well as decreased microvessel density (CD31).In-vivo imaging studies showed significant (p<0.05) migration of PCNCsDi in newly formed vasculature which was 40 folds higher than NCs-Di when determined for total radiance efficiency.The results from our laboratory suggest that theranostic nanoparticles can be successfully used to treat lung cancer.
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