【摘 要】
：
For patients with early stage non-small cell lung cancer (NSCLC) unsuitable for resection, local high-dose stereotactic radiotherapy has been shown an effective treatment approach, combining the accur
【机 构】
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Clinic of Radiation Oncology University Hospital Basel Switzerland
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
For patients with early stage non-small cell lung cancer (NSCLC) unsuitable for resection, local high-dose stereotactic radiotherapy has been shown an effective treatment approach, combining the accurate focal dose delivery by stereotactic techniques with the biological advantages of dose escalated hypofractionated radiotherapy.Treatment regimens with three to five fractions over 1-2 weeks or 1 single fraction as radiosurgery achieve local controls of more than 90 %, with favorable results especially for patients in good general condition.Previous staging procedures should include FDG-PET-CT scan to have the lowest probability of clinical involvement of locoregional lymph nodes.Less than 10% of all patients develop isolated tumor recurrences in regional lymph nodes.Three-year survival is significantly improved to more than 80% when biological effective doses of more than 100 Gy are applied, meaning 3 × 20 Gy for peripheral tumors.In single fraction radiosurgery, 36 Gy seems necessary to achieve similar local control rates, but clinical data is lacking.For centralized tumors, 5 × 8 Gyseems safe and can be recommended, until final results of dose escalation trials are available.There is a broad spectrum of different techniques, often combining image-guidance with stereotactic beam navigation.None of these techniques seems superior to each other, but high experience of the team is mandatory.
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