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  5. Sequential Release Chemotherapeutic Drug with Polymeric Delivery System for Oral Squamous Cell Carci

Sequential Release Chemotherapeutic Drug with Polymeric Delivery System for Oral Squamous Cell Carci

来源 :2014xi`an Conference of International Society for Maxillofac | 被引量 : 0次 | 上传用户：kk831013
【摘 要】
：
Purpose: We developed a ROS-responsive effective drug delivery system to overcoming multidrug resistance(MDR)of oral squamous cell carcinoma(OSCC).Methods: The ROS-responsive crosslinked polymeric mic
【作 者】
：
Liu Bing 
【机 构】
：
Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Harbin Medical Univers
【出 处】
：
2014xi`an Conference of International Society for Maxillofac
【发表日期】
：
2014年4期
【关键词】
：
ROS-responsive Micelles Drug delivery system 
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　　Purpose: We developed a ROS-responsive effective drug delivery system to overcoming multidrug resistance(MDR)of oral squamous cell carcinoma(OSCC).Methods: The ROS-responsive crosslinked polymeric micelles(Cinnamaldehyde-Loaded HPG-7-ethyl-10-hydroxyl-camptothecin,CA-LoadedHPG-SN38)were successfully prepared by the selfassembly of amphiphilic HPG-SN38 and CA.And amphiphilic HPG-SN38 that conjugate via a thioether chain copolymer was characterized using fourier transformed infrared spectroscopy(FTIR),nuclear magnetic resonance(NMR),and gel permeation chromatography(GPC)analysis.CA-Loaded HPG-SN38 Micelles was characterized using transmission electron microscopy(TEM)dynamic light scattering(DLS),critical micell concentration(CC)and Ultra Violet(UV).
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