Arsenic trioxide(ATO)has been found to exert anti-cancer activity in various human malignancies.In our previously reports,we have reported that ATO could inhibits cell growth and invasion via down-reg
目的：研究转录因子FOXO4与大鼠软骨细胞退变的相关性。方法：取4周和16周SD大鼠的软骨，分离软骨细胞；使用甲苯胺蓝染色、阿利新蓝染色及Ⅱ型胶原蛋白免疫细胞化学染色等方法进行软骨细胞鉴定；以1L-1β对大鼠软骨细胞进行诱导退变处理；镜下观察和采用β-半乳糖苷酶染色法进行衰老检测；使用PCR和WesternBlot方法分别检测软骨细胞中FOXO4和Col2α的mRNA表达水平和蛋白表达水平。
Although microRNAs(miRNAs)have been validated to play prominent roles in the occurrence and development of human bladder cancer(BC),alterations and function of many miRNAs in bladder cancer invasion a
To observe the changes of miRNA expression profiles in the brain of aging rats,and their relationship with the expression of learning and memory related genes,and the intervention effect of Reinforcin
Although D-ribose is reputedly a key “anti-aging nutrient” and provided as a supplement to elderly people to improve their health,no laboratories have reported that D-ribose is involved in the product
肠道病毒71型(EV71)属于小RNA病毒科肠道病毒属成员，作为手足口病(HFMD)主要病原体之一，严重威胁公共卫生安全与婴幼儿健康.目前尚无针对EV71感染的特效治疗药物和高效疫苗.EV71的非结构蛋白3C蛋白酶除了能切割病毒多聚蛋白前体，有利于病毒自身蛋白的成熟；还能切割多种宿主蛋白，导致宿主转录和翻译的抑制，有利于病毒逃避天然免疫，促进病毒复制.3C蛋白酶连接宿主与病毒的相互作用，使其成为理
泡沫病毒(foamy virus,FV)属于反转录病毒科泡沫病毒亚科,它在体外培养的细胞或组织中能引起强烈病变效应,但尚未有报道表明它能在天然宿主体内形成致病症状,仅潜伏感染并伴随宿主终身。原型泡沫病毒(prototypefoamy virus,PFV)作为唯一感染人类的泡沫病毒,已经发现数种宿主限制因子可以抑制PFV复制,但PFV感染对细胞基因表达的影响尚待全面深入研究。本实验室前期利用PFV感
Ganoderma lucidum is a rare Chinese traditional medicine which is beneficial to the mind and body,prolonging life used by Chinese medicine.Our previous study found that Ganoderma lucidum miR-01 entere
侵袭转移是恶性肿瘤的最重要的生物学特征。肿瘤细胞的旺盛生长使其对铁需求远大于正常细胞，所以螯合治疗成为一种重要治疗策略。铁螯合剂展示了良好抗肿瘤特性及抑制侵袭转移能力，但作用机理尚未充分阐明。二硫代甲酸衍生物是一类重要的铁螯合剂，能从铁蛋白中萃取铁。细胞增殖评估显示它对HepG2、HCT-116、CT26细胞的生长有较强的抑制作用；克隆形成实验获得相似结果；Balb/c小鼠移植瘤实验表明二硫代甲酸
Tumor chemo-and radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts.Conventional platelet transfusion strategies or drug therapies are used to treat thrombocytopenia.However