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Water-soluble conjugated polymers(CPs)provide a unique platform for chemical and biological sensors in view of their optical signal amplification effect.Water-soluble conjugated polymers(CPs)provide a unique platform for chemical and biological sensors in view of their optical signal amplification effect.Our studies showed that the mesoscale macromolecular assemblies of cationic water-soluble conjugated polymers with biomacromolecules can be used to design and develop conjugated polymers-based biosensors for DNA,RNA,protein as well as metal ions.Very recently,we have developed a new technique for preparing multicolor microparticles based on the self-assembly of bacteria and conjugated polymer nanoparticles(CPNs).They can be successfully applied for cell imaging and optical barcoding.A polythiophene-porphyrin dyad was also prepared for effectively killing neighboring cells.This multifunctional material that simultaneously provides therapeutic action and image the results provide new strategies for the treatment of various diseases.A cationic poly(p-phenylene vinylene)derivate bearing polyethylene glycol(PEG)side chains was also synthesized and used for selective recognition,imaging and killing of bacteria over mammalian cells.These results exhibit that the multi-functional conjugated polymers are ideal platforms for recognition,imaging and disease therapy.