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本研究中的复合型疫苗是采用双疫苗组分-DNA疫苗和重组痘病毒载体疫苗(简称“痘苗”),免疫策略为“prime-boost”方案。本研究设计了DNA单独免疫、复合型疫苗以及痘苗单独免疫1次和2次的毒性研究。并且根据其体液免疫和细胞免疫的特点,检测其免疫原性、免疫毒性相关指标,进行了
The composite vaccine in this study was a dual-vaccine component-DNA vaccine and a recombinant poxvirus vector vaccine (“vaccinia”) with immunization strategy as “prime-boost”. This study designed a single DNA immunization, composite vaccines and vaccinia immunized once and twice the toxicity study. And according to its humoral and cellular immunity characteristics, testing its immunogenicity, immunotoxicity-related indicators were