• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Co-delivery of shRNA and DOX by Smart Gold Nanoparticles for Effective Inhibition of Both Tumor Grow

Co-delivery of shRNA and DOX by Smart Gold Nanoparticles for Effective Inhibition of Both Tumor Grow

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：snakegmj
【摘 要】
：
Metastasis, the main cause of cancer related deaths, remains the greatest challenge in cancer treatment.In the present study, an attempt to simultaneously inhibit the metastasis and growth of tumor by
【作 者】
：
Feihu Wang Yuanyuan Shen Wenjun Zhang Shengrong Guo 
【机 构】
：
School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China;Sha
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
Metastasis Gold nanorods Disulfide-linked polyethylenimine shRNA Doxorubicin 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Metastasis, the main cause of cancer related deaths, remains the greatest challenge in cancer treatment.In the present study, an attempt to simultaneously inhibit the metastasis and growth of tumor by co-delivering p65 shRNA to block NF-kB signaling pathway and anticancer drug doxorubicin (DOX) using a PEGylated, RGD peptide modified, and disulfide cross-linked short polyethylenimines (DSPEIs) functionalized gold nanorod (RDG) on metastatic MDA-MB-435 breast cancer cell line and its pulmonary metastasis mice model.
其他文献
Co-delivery of doxorubicin and miR-34a for androgen independent prostate cancer based on reduction-r
Co-delivery of chemotherapeutic drug and microRNA is a promoting strategy for tumor therapy due to its synergistic effect.In our study, hydrophobic doxorubicin (DOX) and negative miR-34a were simultan
会议
Fast Crystallization behaviors of Amorphous Pharmaceutical Solids
Amorphous solids are generally more soluble and faster dissolving than their crystalline counterparts, which makes them useful for delivering poorly soluble drugs whose bioavailability is limited by t
会议
Controlled Synthesis, Modification and Assembly of Multifunctional Nanoparticles for Targeted Drug D
Nanotechnology has received extraordinary attention recently due to its burgeoning role in pharmaceutical research.The materials composing the nanoparticles produce fascinating and diverse functionali
会议
The Effect of Formulation on Pharmaceutical Process and Scale-up
Manufacturability is one of the important properties of later stage and launched pharmaceutical products.Suitable process and robust process parameter control are the keys for a well controlled produc
会议
Thermosensitive hydrogel of Doxycycline-PECT exerts inhibitive effects on abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a severe degenerative disease characterized by degradation of extracellular matrix (ECM) with increased matrix metalloproteinases (MMPs) and inflammatory reaction.Do
会议
Abdominal aortic aneurysmdoxycyclinePECTthermosensitive hydrogelsanti-AAA me
Enhanced Cellular Entry Efficiency of Cell-Penetrating Peptide Conjugates by Rational Molecular Desi
Cellular entry is among the key steps that determine the biological effects of drugs and imaging probes whose targets are cytoplasm located.To facilitate the trans-membrane cargo delivery, one feasibl
会议
Intestinal OCTN2 transporter as a target for enhanced oral delivery for small-molecule prodrug and L
The organic cation/camitine transporter (OCTN2) is a high affinity cation/carnitine transporter widely expressed in human tissues, including skeletal muscle,kidney, brain, heart,and placenta.OCTN2 is
会议
organic cation/carnitine transporter (OCTN2)prodrugintestinal nanoparticlescy
Preparation and characterization of poor-soluble drug ZR inclusion compounds using supercritical flu
This study aims to develop a green supercritical fluid (SCF) technology in the preparation of inclusion compounds of poor-soluble drug with cyclodextrin.A traditional Chinese medicine ——ZR was chosen
会议
supercritical fluid technologyinclusion compoundpoor-soluble drug
Fenofibrate Nanoliposome: Preparation and Its Inhibition Effects on Nonalcoholic Fatty Liver Disease
Objective: To prepare fenofibrate nanoliposome (FNB-Nanolipo) and investigate its characterizations, oral pharmacokinetic profiles as well as its inhibition effects on nonalcoholic fatty liver disease
会议
fenofibrateliposomebioavailabilitynonalcoholic fatty liver diseasemethionine
Biomimetic Nanoparticles for Targeted Co-Delivery of SiRNA and Small-Molecule Drugs in Combined Anti
Objective Both angiogenesis and tumor cell proliferation are the main features of tumor tissues.The proliferating tumor cells require nutrients as well as oxygen and stimulate the formation of new blo
会议