Transgenic expression of N-tau in neuronal precursor cells decreases adult hippocampal neurogenesis,

来源 :The 11th transgenic Technology Meeting ISTT2013 ( 第十一届国际转基因技 | 被引量 : 0次 | 上传用户：dragon624

【摘要】

：

Different tau pathological species affect brain plasticity an cause memory loss in several neurodegenerative diseases associated with dementia.However, little i

【作者】

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Georgios Strimpakos Vincenzo Cestari Elisabetta Mattei Nadia Canu Andrea Pdsterà Daniele Saraulli Stefano Farioli-Vecchioli Marco Costanzi Maria Grazia di Certo Sara Cannas Maria Teresa Ciotti Felice

【机构】

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InstituteofCellBiologyandNeurobiology,NationalResearchCouncil,Rome,ItalyInstituteofCellBiologyandNeu

【出处】

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The 11th transgenic Technology Meeting ISTT2013 ( 第十一届国际转基因技

【发表日期】

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2013年2期

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Different tau pathological species affect brain plasticity an cause memory loss in several neurodegenerative diseases associated with dementia.However, little is known about how disease-associated tau modification(s) may affect adult hippocampal neurogenesis, a unique form of structural plasticity implicated in hippocampus-dependent spatial learning and mood-related behavior.

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Transgenic expression of N-tau in neuronal precursor cells decreases adult hippocampal neurogenesis,

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