【摘 要】
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Autism (MIM 209850)is a complex neurodevelopmental disorder characterized by social communication impairments and restricted repetitive behaviors.It has a h
【机 构】
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中南大学生命科学学院(医学遗传学国家重点实验室) 湖南省长沙市湘雅路110号,410078
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Autism (MIM 209850)is a complex neurodevelopmental disorder characterized by social communication impairments and restricted repetitive behaviors.It has a high heritability, although much remains unclear.To evaluate genetic variants of GRIN2B in autism etiology, we performed a system association study of common and rare variants of GRIN2B and autism in cohorts from a Chinese population, involving a total sample of 1,945 subjects.Meta-analysis of a triad family cohort and a case-control cohort identified significant associations of multiple common variants and autism risk(Pmin=1.73 × 10-4).
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