Background and Aims The molecular mechanisms of impaired liver regeneration in several liver diseases remain poorly understood.Endoplasmic reticulum (ER) stress has been observed in a variety of liver diseases.The aims of this study were to explore the impacts of ER stress on hepatocyte proliferation and c-Met expression in human hepatocyte L02 cells.Methods Human hepatocyte L02 cells were incubated with thapsigargin (TG) to induce ER stress.