【摘 要】
：
Diabetes mellitus results in neuropathy of both somatic and visceral nerves.Here, we investigated the colorectal mechanosensitivity and pelvic nerve sensiti
【机 构】
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Department of Physiology,Shanghai Jiaotong University School of Medicine,280 South Chongqing Road,Sh
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Diabetes mellitus results in neuropathy of both somatic and visceral nerves.Here, we investigated the colorectal mechanosensitivity and pelvic nerve sensitivity in experinental diabetes.The viscero-motor responses (VMRs) were assessed by recording the EMG of abdominal muscles in response to colorectal ramp distension (CRD, 0-80 mmHg).In addition, the colorectal region was removed en bloc, the activity of a fine branch of the pelvic nerve was recorded in response to the ramp distension (0-60 mmHg).VMRs were significantly decreased to CRD intensities from 40 to 80 mm Hg in rats following STZ injection compared to that in control animals.The mechanosensory responses of low threshold fibers and wide dynamic range units to distension intensities from 15 mmHg to 60mmHg in STZ-induced diabetic rats were smaller than in control rats.These findings suggest that diabetes leads to functional deficits of colorectal mechanosensitivity.
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