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Several studies have implicated the dorsomedial hypothalamic nucleus (DMN) in regulation of feeding behavior and body weight,but clear mechanisms by which it controls food intake are not well understood.Here we report that DMN received important peripheral short-term and long-term feeding-related afferent signals,including the gaswic vagal inputs,glycemia,cholecystokinin (CCK) as well as leptin,an adipostatic signal forcefully inhibiting food intake and increasing metabolic rate.Among the 279 DMN neurons recorded,173 (62.0%) responded to the stimulation of gastric vagal nerves.