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5. The Importance of Ligands on G-protein Coupled Receptor Stability

The Importance of Ligands on G-protein Coupled Receptor Stability

来源 :上海浦东免疫化学国际生物论坛 | 被引量 : 0次 | 上传用户：wisdom76

【摘 要】

：

Traditionally, G protein-coupled receptor (GPCR) activity has been characterized by ligand properties including affinity (Ki), potency (IC50/EC50), efficacy (Em

【作 者】

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Xianjun Zhang Fei Xu 

【机 构】

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iHumanInstitute,ShanghaiTechUniversity,99HaikeRoad,Building6,2ndFloor,Shanghai,201210,China

【出 处】

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上海浦东免疫化学国际生物论坛

【发表日期】

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2015年11期

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论文部分内容阅读

Traditionally, G protein-coupled receptor (GPCR) activity has been characterized by ligand properties including affinity (Ki), potency (IC50/EC50), efficacy (Emax), and kinetics (Kon/Koff).These properties are related to ligand residence time, a general index of drug-target interaction in vivo.

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