【摘 要】
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Chitosan(CS)is a natural,cationic amino polysaccharide copolymer with favorable biological properties such as biodegradability,biocompatibility and non-toxi
【机 构】
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School of Materials Science and Engineering,Tsinghua University,Beijing 100084,China
【出 处】
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The 5th International Congress on Ceramics, ICC5(第五届国际陶瓷大会)
论文部分内容阅读
Chitosan(CS)is a natural,cationic amino polysaccharide copolymer with favorable biological properties such as biodegradability,biocompatibility and non-toxicity.Combined with β-glycerophosphate disodium(β-GP),CS is an outstanding in situ gel-forming system.This system is thermo-sensitive and thus applied in construction of injectable scaffold for tissue engineering.On the other hand,the modification of chitosan has been widely studied in order to get certain additional advantageous properties.Different from unmodified chitosan,which can only be dissolved in some acid medium,the thiolated chitosan performs good solubility at neutral pH.Moreover,the immobilized thiol groups are able to form disulfide bonds with other thiol groups in proteins,resulting in the improvement of mucoadhesion.
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