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Infected bone defects are normally regarded as contraindications for bone grafting.In the present study,a new antibacterial bone graft substitute has been developed for repairing bone defects and inhibiting related infections simultaneously.Calcium sulphate hemihydrate(CSH)was introduced into nano-hydroxyapatite/collagen(nHAC)to prepare a self-setting in situ bone repair materials nHAC/CSH,which was used as a carrier of vancomycin(VCM)for anti-infection and the treatment of osteomyelitis.