【摘 要】
：
Patients with long-standing diabetes often demonstrate gastric hypersensitivity with an unknown mechanism.The present study was designed to investigate roles for NF-kappa B and the endogenous H2S prod
【机 构】
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Institute of Neuroscience, Suzhou Key Laboratory of Pain Research and Therapy, Soochow University,Su
【出 处】
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中华医学会疼痛学分会第十一届学术年会
论文部分内容阅读
Patients with long-standing diabetes often demonstrate gastric hypersensitivity with an unknown mechanism.The present study was designed to investigate roles for NF-kappa B and the endogenous H2S producing enzyme cystathionine-beta-synthetase (CBS) signaling pathways in adult female rats with experimental diabetes.Here, we showed that injection of STZ produced gastric hypersensitivity in female rats in response to gastric balloon distention in association with upregulation of CBS and p65 expression in gastric DRGs.Treatment with CBS inhibitor AOAA significantly attenuated gastric hypersensitivity.
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