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Immunoglobulin D (IgD) has remained a mysterious antibody class since its discovery in 1964.The structure of IgD has been very dynamic throughout evolution.And also the function of IgD has been warmly discussed.On one hand, membrane IgD (mIgD) is found as an antigen receptor on the surface of the majority of human and murine B cells prior to antigenic stimulation.On the other hand, secreted IgD (sIgD) can bind to a putative IgD receptor (IgD-R) as a ligand.The dual effects make it hard to clarify IgDs function and mechanism.Recent research shows that serum IgD level changes significantly in some autoimmune diseases and IgD BCR cross-link can lead to a T-B cell interaction.This review will mainly talk about the potential role of IgD in rheumatoid arthritis (RA) through influencing T and B lymphocytes.