【摘 要】
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Background The differentiated function of endothelial progenitor cells (EPCs) may play an pivotal roles in endothelial repair and reendothelialization replacement of postinjury endothelium, However, t
【机 构】
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Institute of Cardiovascular Disease,Xinqiao Hospital,Chongqing,China
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Background The differentiated function of endothelial progenitor cells (EPCs) may play an pivotal roles in endothelial repair and reendothelialization replacement of postinjury endothelium, However, the mechanism of differentiation of EPCs remains unclear.One of zinc finger transcription factors family members, KLF4, was involved in the regulation of numerous biological processes including proliferation, differentiation, development, and apoptosis.This present study was designed to investigate whether transcription factors, Krüppel-like factor 4 (KLF4) is involved in the differentiation of EPCs derived from bone marrow (BM-EPCs) into endothelial cells (ECs).
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