【摘 要】
：
Symbiotic fungi have been witnessed to be a rich source of novel natural products with unforeseeable architectures and excellent biological activities.Recent attempts for drug discovery emphasize that
【机 构】
：
Nanjing University.School of life science, Nanjing University Xianlin Campus, Xianlin Road No.163, Q
【出 处】
：
2015年上海市研究生学术论坛(生物化工)
论文部分内容阅读
Symbiotic fungi have been witnessed to be a rich source of novel natural products with unforeseeable architectures and excellent biological activities.Recent attempts for drug discovery emphasize that fungal natural products still are animportant source for the development of pharmaceutical industry(Nat Prod Rep, 2014, 31, 35-60).However, the modifications of complex natural compounds are generally difficult or economically unfeasible.This bottleneck has spurred the innovation of mutasynthesis which can provide complex analogues by making use of the broadness of substrate of some enzymes involved in biosynthetic pathway of secondary metabolites (Nat Prod Rep, 2008, 25, 475-516).By usingfungal mutations that are deprived abilities of producing natural substrates, we can acquire structurally modified compounds derived from unnatural precursors with higher isolation yields.
其他文献
In the production of L-lactic acid, the residual sugar that were difficult to be used by the microorganism in the broth would lead to the increased sugar content in its commercial products,bringing la
Dalesconols (dalesconols A and B) arc novel polyketides with strong immunosuppressive activity produced by Daldinia eschscholzii.In this work, the effects of different media (M1, M2, and M3) on fungus
Backgrounds: In this study, the performance of aerobic batch fermentation with Aspergillus niger producing sodium gluconate under different oxygen supply levels through adjusting the agitation rate we
This paper hinged on the combination effect of two different neutralizing agents Ca(OH)2and NH4OH on the production of L-lactic acid by Lactobacillus paracasei.Present study quantitatively indicated t
The effects of Ca(OH)2, NH4OH and NaOH as neutralizing agents on the efficiency of l-lactic acid production by Lactobacillus paracasei were investigated in this study.Fermentation performance with Ca(
Enantioselective hydrolysis of racemic epoxides mediated by epoxide hydrolases (EHs) is one of the most promising approaches to obtain enantiopure epoxides.In this study, we identified and characteriz
Curvulamine is a novel alkaloid with strong antimicrobial activity produced by the marine-derived fungus Curvularia sp.IFB-Z10.In this work, the effect of different carbon and nitrogen source on the c
果胶和木聚糖是存在于自然界中非常丰富的可再生资源，但有时这些资源并没有得到很好地发掘和利用，反而造成了环境污染。有效地转化和利用这类丰富的可再生资源需要多种酶的共同参与，其中α-L-阿拉伯呋喃糖苷酶起着非常重要的作用，是本课题的研究重点。它减少阿拉伯糖侧枝产生的空间位阻，使得内切型酶更易结合和分解聚糖主链，从而大大增加水解效率。本研究主要包括以下四个部分。
Reversible lysinc acetylation (RLA) is used by cells of all domains of life to modulate protein function.To date, bacterial acetylation/deacetylation systems have been studied in a few bacteria (e.g.,
From an environmental perspective, utilizing nonconventional solvents (i.e.green solvents) with low ecological footprint is a highly beneficial alternative to the conventional organic solvents to form