【摘 要】
：
Apolipoprotein C-Ⅲ (apoC-Ⅲ) is a small, interchangeable apolipoprotein present in HDL, VLDL and to a much smaller extent in LDL.We have shown that apoC-Ⅲ is a strong inhibitor of the clearance ofVLDL,
【机 构】
：
School of Medicine Universidad de los Andes Colombia
论文部分内容阅读
Apolipoprotein C-Ⅲ (apoC-Ⅲ) is a small, interchangeable apolipoprotein present in HDL, VLDL and to a much smaller extent in LDL.We have shown that apoC-Ⅲ is a strong inhibitor of the clearance ofVLDL, IDL and LDL in vivo in humans.The result of the inhibition of VLDL and IDL clearance is a prolongation of their intravascular halflife, which leads to the formation of small, dense LDL.Besides its deleterious effects on lipoprotein metabolism, apoC-Ⅲ has several direct proatherogenic properties on the vascular wall, increasing expression of adhesion molecules by endothelial cells and monocytes, and inducing a dysfunctional, insulin-resistant phenotype in endothelial cells.
其他文献
BACKGROUND The efficacy of radiofrequency (RF) ablation of an uncommon coronary sinus (CS)-dependent atrial flutter (AFL) was evaluated using conventional electrophysiological criteria in a highly sel
The association of metabolic syndrome (MetS) and renal impairment with atrial fibrillation was reported in several epidemiological studies [1-4].However, only few previous studies analyzed the role of
Cardiopulmonary support with extracorporeal membrane oxygenation (ECMO) is widely used in large centers that perform heart surgery or have a well-defined and reasoned program for it.This treatment met
Pulmonary hypertension is a frequent and severe complication in the postoperative period of pediatric congenital cardiac surgery and can lead to adverse developments with severe myocardial dysfunction
Transcatheter aortic valve implant (TAVI) is the new most exciting treatment for aortic stenosis (AS) in the past two decades, looking aortic valve replacement (AVR), which is one of the most effectiv
Penetrating injuries to heart are fatal in a significant percentage of patients so injured.In fact many patients are found dead at the site of injury.However ,patients who arrive at the hospital with
Postoperative sternal wound complications (PSWC) are infrequent events which nonetheless negatively affect recovery and rarely may have very serious consequences.Sternal wrapping (SW), an alternative
In percutaneous coronary interventions (PCI), a complex lesion may be classified according to anatomic criteria, including extensive calcification, thrombus, and chronic occlusions, or by location, su
Total arterial revascularization using bilateral internal mammary artery for coronary artery disease has shown to have excellent long term results.LIMA-RIMA-Y (left internal mammary artery and right i
Primary angioplasty is the treatment of choice for ST elevation myocardial infarction.Any time delay in revascularization affects infarct size and increase 1-year mortality.In our center we shorten th