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The methylation statuses of genome DNA play critical roles in transcriptional regulation of gene expression,thereby being recognized as an important epigenetic marker or regulator in many biological processes and in complex diseases such as cancer.Here we performed a comprehensive survey of the promoter DNA methylation profiles of more than 7000 tumors and hundreds of matched adjacent normal tissues from 21 cancer types in The Cancer Genome Atlas (TCGA) consortium,at the resolution of single-CpG site.