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Recently reports on the role and mechanism of Integrin/Focal adhesion kinase (FAK)/ERK signal pathway in many malignant tumor progressions, including colon cancer have been popularly published.The claudin family of proteins is integral to the structure and function of tight junction.However, studies have revealed roles of tight junction proteins including claudins in the regulation of proliferation, migration and epithelial differentiation in addition to their known role in epithelial barrier function.