SLFN11抑制原型泡沫病毒PFV复制功能及机制初探

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：caculate

【摘要】

：

泡沫病毒(foamy virus,FV)是一类特殊的反转录病毒,能感染体外培养的细胞,引起细胞病变死亡,但其在体内并不引发任何病症,仅保持持续感染并伴随宿主终身,机体的免疫系统在此过程中发挥了重要作用.宿主限制性因子是指在病毒复制过程的某个特定步骤与病毒相互作用,从而阻断病毒复制的宿主蛋白.Schalfen(Slfn)家族蛋白可以抑制细胞增殖、调控造血细胞及T细胞分化等免疫应答活动,近年来发现其具

【作者】

：

郭鸽胡笑梅解英朋乔文涛

【机构】

：

南开大学生命科学学院,分子微生物学与技术重点实验室(教育部),天津,300071

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

泡沫病毒 SLFN11

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SLFN11抑制原型泡沫病毒PFV复制功能及机制初探

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