The rapid increase of health-threatening infections by Gram-negative pathogens along with the emergence of multidrug-resistant bacterial strains demands the development of novel antibiotics directed a
4-Chloroindazole(1)has been identified as an important building block for the synthesis of many biologically active 4-substituted indazole derivatives,including ABT-8691 and ABT-1022,etc.
Protein kinase CK2 is involved in a variety of important cellular physiological processes and aberrant CK2 activity is associated with a wide variety of human diseases [1].
Camptothecin(CPT)is a pentacyclic alkaloid that was isolated by Wall and Wani from Camptotheca acuminate in 1966,and show potent inhibitory activity against a broad spectrum of tumors.
1,2,3-Triazoles are an important class of heterocyclic compounds.They are shown to have different biological activities,such as antitumor1,anti-HIV2 and so on.