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We divided randomly SD rats into sham group, chronic constriction injury (CCI) group, CCI+allogeneic olfactory bulb tissue transplantation(CCl+AOBTT) group.Mechanical withdrawal threshold (MWT) and thermal withdrawal latency(TWL) of rats were measured before operation, ld,3d, 7d and 14 d after operation.Spinal ganglion and spinal cord of L4 and L5 of rats were removed in the 7 d and 14d after operation, RT-PCR and immunohistochemical methods were used to detect the changes of P2X3 receptor mRNA and protein level.