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5. An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide

An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：tp20201892

【摘 要】

：

The synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide as the internal electrophilic group,t-BuLi as the lithium reagent was described.The reaction was very efficient and cou

【作 者】

：

Chaolei WANG Zheng WU Jia WANG Jie LIU Jinyi XU 

【机 构】

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State Key Laboratory of Natural Medicines,China Pharmaceutical University,24 Tong Jia Xiang,Nanjing

【出 处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

4-isochromanones Parham-type cyclization Weinreb amides (±)-XJP Acknowledgment 

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　　The synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide as the internal electrophilic group,t-BuLi as the lithium reagent was described.The reaction was very efficient and could be completed in only one minute.

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