Aim: This study was conducted to evaluate the prevalence of FSH autoantibodies in aging male and further observe the correlation between FSH autoantibodies and reproductive hormones.Methods: The serum
Objective: The differentiation of male germ cells from iPS cellsprovides an ideal model for unveiling molecular mechanisms of spermatogenesis.Nodal could promote proliferation of mouse spermatogonial
Objective: The previous genome-wide association study (GWAS) of non-obstructive azoospermia (NOA) in the Han Chinese populations identified two NOA-risk loci (rs498422 and rs3129878) within the HLA re
Background: Because available definitions of premature ejaculation (PE) were unable to encompass the various forms of PE, Waldinger et al.proposed a new classification that distinguished four PE syndr
To examine whether urinary tract nerve growth factor (uNGF) could be a biomarker for overactive bladder (OAB) symptom, we conducted a comprehensive meta-analysis of 8 case-control studies.In all the s
The large conductance voltage-and Ca-activated K(BK) channel is a critical regulator of urinary bladder smooth muscle (UBSM) excitability and contractility in many species.BK channel activation can hy
Objectives: To assess the etiological diagnostic value of magnetic resonance imaging (MRI) by analysis of the pelvic MRI manifestations or characteristic changes around the ejaculatory duct area and t
Meta-analysis Polymorphism Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive.To drive a more precise estimation, we performed a meta-analysis based on 1,06
目的:FISH分析外周血AZF无缺失的严重少精子症患者精子AZFc缺失情况.方法:实验组包括16例外周血检测未见AZF缺失的严重少精子症患者,选择2例已经正常怀孕的男性作为阳性对照组,选取2例AZFc缺失的少精子症患者作为阴性对照.应用荧光原位杂交法检查精子中AZFc缺失情况,选用18号染色体着丝粒探针为参照,SRY作为Y染色体特异性信号,DAZ基因作为AZFc特异性信号.每组观察100个精子,分
目的:许多男性不育的病因不明,然而,弱精症作为一种常见的特发性男性不育,应该更加受到关注.目前证实,有大量与精子运动性相关的基因,与突变相比,基因多态性在特发性弱精症中可能扮演了一个非常重要的作用.资料显示NO在精子发生过程中发挥着巨大的作用,而NO水平潜在影响人类精子的运动性.除了内皮细胞,NO合酶(eNOS)也表达了在支持细胞和生殖细胞.由于其广泛表达在人类睾丸的多种类型的细胞,因此eNOS与