In recent years, photodynamic therapy (PDT) have been developed and widely used in the clinic to cancer treatment.However, PDT usually requires lights to activate photosensitizers to generate reactive oxygen species (ROS) for killing tumors.The major challenges are the limited depth of tissue penetration of the light and poor cancer cell/tissue targetability.Recently, magnetic nanoparticles (MNPs) are proved to exhibit the enzyme-mimic activity, Fe2+/Fe3+ ions on the surface of MNPs can catalyze the decomposition of hydrogen peroxide (H2O2) to generate the ROS that have the strong oxidized ability to organisms.