Understanding the Biophysical Origin of Protrusive Blisters in Sonoporated Cells: Actin Network Disr

来源 :2015两岸超声技术与医学研讨会 | 被引量 : 0次 | 上传用户:aiyanxiyanxi
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Background, Motivation and Objective Protrusive membrane blisters have often been observed on the surface of sonoporated cells that were subjected to acoustic cavitation exposure. Alas, why these blisters would emerge remain unknown, and providing answers would be important to understand how cells may strive to restore plasma membrane integrity in a sonoporation episode. Such a research topic is especially relevant to sonoporation episodes that were triggered locally by targeted microbubbles bordering the plasma membrane, because resulting cavitational impact would be discharged firsthand to the cell. Here, we seek to test the hypothesis that the blisters are membrane blebs that arise due to acute disruption of cytoskeleton during sonoporation, and that this phenomenon is part of the sonoporated cells anti-stress machinery.
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