【摘 要】
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Background Linkage has been reported between allelic variations in HLA-DR and Parkinsons disease (PD), but the polymorphisms were found to be different ethnically and geologically.HLA-DR and PSMB, TAP
【出 处】
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第九届全国帕金森病及其他运动障碍疾病学术研讨会
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Background Linkage has been reported between allelic variations in HLA-DR and Parkinsons disease (PD), but the polymorphisms were found to be different ethnically and geologically.HLA-DR and PSMB, TAP loci are all located in the HLA class Ⅱ region, and they play important roles in both immune response and protein degradation in neurodegenerative diseases.To date, little research has been performed to investigate the association between PD and polymorphisms of HLA-DRA, PSMB and TAP in Han Chinese.To investigate the association between the polymorphism of HLA class Ⅱ region and sporadic PD in Han Chinese population, a case-control study was performed through genotyping single nucleotide polymorphisms (SNPs) in HLA-DRA, PSMB8, PSMB9, TAP1, and TAP2 genes.
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