【摘 要】
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Purpose:To assess the use of RL/G of γ-H2AX (ratio of γ-H2AX in lymphocytes to that in granulocytes ) in blood as a rapid method for population triage and doses estimation in events of large-scale rad
【机 构】
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Department of Radiation Toxicology and Oncology,Beijing Institute of Radiation Medicine,27 Taiping R
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Purpose:To assess the use of RL/G of γ-H2AX (ratio of γ-H2AX in lymphocytes to that in granulocytes ) in blood as a rapid method for population triage and doses estimation in events of large-scale radiation emergencies.Materials and methods:Blood samples from healthy volunteers exposed to 0-10Gy of 60Co irradiation and cultured for 0-24h were analysed using flow cytometry assay to measure γ-H2AX levels in lymphocytes and granulocytes.The basal levels of RL/G of γ-H2AX in health human blood,the response of RL/G of γ-H2AX to ionizing radiation and its relationship to doses,time intervals after exposure,and individual differences were analyzed in our study.
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