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  5. DACT2 is Frequently Methylated in Human Gastric Cancer and Methylation of DACT2 Activated Wnt Signal

DACT2 is Frequently Methylated in Human Gastric Cancer and Methylation of DACT2 Activated Wnt Signal

来源 :第四届国际肿瘤表观遗传学大会 | 被引量 : 0次 | 上传用户：eddiechen3
【摘 要】
：
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of the Wnt signaling pathway.The purpose of this study is to explore the epigenetic changes and the function of DACT2
【作 者】
：
Yuanzi YU Wenji Yan Xuefeng Liu Yan Jia Baoping Cao Yingyan Yu Youyong Lv Malcolm V.Brock Jame G.Herman Julien Licchesi Yunsheng Yang Mingzhou Guo 
【机 构】
：
Department of Gastroenterology & Hepatology, Chinese PLA General Hospital, ＃28 Fuxing Road, Beijing
【出 处】
：
第四届国际肿瘤表观遗传学大会
【发表日期】
：
2014年8期
【关键词】
：
Gastric cancer Dact2 DNA methylation Wnt signaling pathway chemo-sensitivity 
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Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of the Wnt signaling pathway.The purpose of this study is to explore the epigenetic changes and the function of DACT2 in human gastric cancer (GC).Eight human gastric cancer cell lines, 169 samples of primary gastric cancer and 8 samples of normal gastric mucosa were used in this study.
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