Background, Motivation and Objective This study investigates the performance of a novel power ultrasonic bone biopsy needle by assessing damage induced during the penetration of the resonant device into bone tissue. Bone biopsy is a relatively simple but crude medical procedure which performs the removal of a small bone or bone marrow sample during the diagnosis of medical conditions such as primary and secondary bone tumours, leukemia, multiple myeloma or Paget’s disease. However, to penetrate bone tissue, the surgeon has to apply a large force through the needle, which can cause damage to soft tissue surrounding the biopsy site and induce bone fractures. By utilizing micrometric vibrations developed by the ultrasonic device, the force required to penetrate bone tissue is significantly reduced and there is less damage to tissue.