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  5. Effects of NS398 on Metastasis-associated Gene Expression in a Human Colon Cancer Cell Line Detected

Effects of NS398 on Metastasis-associated Gene Expression in a Human Colon Cancer Cell Line Detected

来源 :2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会) | 被引量 : 0次 | 上传用户：lv53647678
【摘 要】
：
Aim:N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS398),is a highly selective-2 inhibitor.It is not only used in the anti-inflammation,but more and more studies are dedicated to the researc
【作 者】
：
Xue-Qin Gao Jin-Xiang Han Hai-Yan Huang Chang-Zheng Song Bo Zhu Xue-Qin Gao Jin-Xiang Han 
【机 构】
：
Key Laboratory of Ministry of Health for Biotech-Drug, Shandong Medicinal and Biotechnology Center,
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
【发表日期】
：
2005年12期
【关键词】
：
NS398 colorectal cancer gene expression metastasis cDNA microarray 
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　　Aim:N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS398),is a highly selective-2 inhibitor.It is not only used in the anti-inflammation,but more and more studies are dedicated to the research on its anticancer effects.Its mechanism in anticancer effects involves many signal pathways.One is induction of apoptosis of different tumor cells.Its inhibitory effects on the metastasis in vitro and in vivo were mainly mediated by regulating the MMP family components.NS98 can inhibit the invasiveness of prostrate cancers by and reducinge the release of MMP-2 and MMP-9 and increase of TIMP-2,but not TIMP-1 [4].
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