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Background: Staphylococcus aureusis a virulent pathogen that is commonly found in hospitals and community environments.Methicillin-resistance S.aureus (MRSA),which has developed resistance to almost all kinds of antibiotics,is a pathogen that is responsible for over 50%S.aureusinfections worldwide and the mortality rate of MRSA infection is more than 20%.Due to its multi-drug resistance,it is challenging to control and treat this pathogen with standard antibiotic treatment.Vancomycin has been considered the last-resort treatment; however,even vancomycin-resistant S.