【摘 要】
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High-risk carcinogenic subtypes of human papilloma virus (HPV) are associated with the development of squamous cell carcinomas of the cervix (CC) and a subset of head and neck (HNSCC).Recurrent metast
【机 构】
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Centre for Cancer Therapeutics, Ottawa Hospital Research Institute Canada
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High-risk carcinogenic subtypes of human papilloma virus (HPV) are associated with the development of squamous cell carcinomas of the cervix (CC) and a subset of head and neck (HNSCC).Recurrent metastatic diseases of these sites display a dismal prognosis.Therefore, there is an urgent need to uncover innovative therapeutic strategies in this clinical setting.Oncolytic viruses, including vesicular stomatitis virus (VSV), were identified due to their ability to specifically target tumor cells that generally display defects in interferon (IFN) signaling.
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