Antisense antibiotics: mission possible or impossible?

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户:dong770527
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The nightmare of multi-drug resistant bacteria will still haunt if no panacea is ever found.Efforts on seeking desirable natural products with bactericidal property and screening chemically modified derivatives of traditional antibiotics have lagged behind the emergence of new multi-drug resistant bacteria.
其他文献
The voltage-gated KCNQ/M-potassium channels play a principal role in controlling neuronal excitability.Mutations or inhibition of KCNQ/M-channels can cause neurological diseases, such as myokymia and
Aim: Our previous studies have revealed behavioral sensitization, closely relating to drug addiction, mediated by chaperone heat shock protein 70 (Hsp70) in mice.This study aimed to investigate the ef
Aim: Guttiferone K (GutK) is a novel cytotoxic compound able to selectively induce apoptosis in colorectal cancer cells.The study proposes endoplasmic reticulum (ER) stress aggravation as the underlyi
Aim: Loss of glycosaminoglycan (GAG) chains isa typical pathological change of osteoarthritis (OA).Here, effects of Angelica sinensis polysaccharides (ASPs) on GAG synthesis in chondrocytes and the me
Aim: Adverse drug reaction (ADR) means a reaction which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modi
Aim: JD-30 is an active fraction extracted from Danggui-Shaoyao-San under guidance of bioactive evaluation in our previous studies.It has been reported that JD-30 could ameliorate cognition disorders
Aim: Long acting luteinizing hormone-releasing hormone (LHRH) antagonists designed to be protease-resistant were a series of novel decapeptides structurally similar to LHRH.in this study, a high-throu
Aim: Posttraumatic nightmares are a prevalent and distressing symptom of posttraumatic stress disorder (PTSD).In this study, we found some rats wake up with a start after traumatic stress and investig
Aim: Neuraminidase (NA) is one of the most important drug targets for antiinfluenza drugs, NA inhibitors are currently the main clinical medicines for the treatment of influenza virus infection, and m
Aim: To discover the new drugs of treating cerebrovascular disease by conatructing a new pharmacology evaluation system.Methods: Under the thoughts of "mimic clinics", we first developed animal model