【摘 要】
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Type 2 diabetes mellitus is associated with progressive decreases in pancreatic 8-cell function.Most patients thus require increasingly intensive treatment,including oral combination therapies followe
【机 构】
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Department of Endocrinology Diabetology and Metabolism Faculty of Medicine Antwerp University Hospit
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Type 2 diabetes mellitus is associated with progressive decreases in pancreatic 8-cell function.Most patients thus require increasingly intensive treatment,including oral combination therapies followed by insulin.Fear of hypoglycemia and weight gain is a potential barrier to treatment adherence and glycemic control,while weight gain can exacerbate hyperglycemia or insulin resistance.Administration of insulin can roughly mimic physiologic insulin secretion but does not address underlying pathophysiology.Glucagon-like peptide 1 (GLP-1) is an incretin hormone released by the gut in response to meals that helps to maintain glucose homeostasis through coordinated effects on islet α-and B-cells,inhibiting glucagon output,and stimulating insulin secretion in a glucose-dependent manner.Biological effects of GLP-1 include slowing gastric emptying and decreasing appetite.
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