【摘 要】
：
In recent research of proteome, isolation and detection of biomarkers from complex biological samples, such as serum, urea, cerebrospinal fluid and so on, a
【机 构】
：
Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R&A Center,
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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In recent research of proteome, isolation and detection of biomarkers from complex biological samples, such as serum, urea, cerebrospinal fluid and so on, are of great significance.But, the fact is that nearly all of these biomarkers are low abundance proteins, and the signals of these in mass spectrum are usually concealed by high abundance proteins, which is one of the greatest challenges in the current proteomics study.Therefore, an effective method to eliminate high abundance proteins from samples is critical.
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