【摘 要】
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The present study cultured and separated breast cancer stem cells (CSCs) to produce a vaccine,and the safety and efficacy of the vaccine was evaluated in low-, medium-and high-dose groups.Between Janu
【机 构】
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Department of Biological Treatment Center, Fuda Cancer Hospital,Jinan University School of Medicine,
【出 处】
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2016第五届国际(广州)癌症治疗论坛暨国际干细胞再生医学学会成立大会
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The present study cultured and separated breast cancer stem cells (CSCs) to produce a vaccine,and the safety and efficacy of the vaccine was evaluated in low-, medium-and high-dose groups.Between January and September 2014, the present study enrolled 90patients that met the enrolment criteria and they were assigned to the three groups (n=30).Throughout the study, injection site reaction was the most common reaction the patients experienced (86%), while fever was the least common reaction (36%).However, there was no difference between the three groups.When the CSC-specific and non-specific immune responses were compared pre-and post-vaccination, it was found that the CSC-non-specific immune response of all three groups was significantly enhanced, and there was a clear increase in the CSC-specific immune response in the medium-and high-dose groups.This study is the first clinical trial of a breast CSC vaccine, and preliminarily demonstrates safety and efficacy of the vaccine.
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