【摘 要】
：
The ATR pathway controls chromosome integrity and chromatin dynamics.We recently found that ATR, ATRIP and Chk1 associate to the nuclear envelope during S phase and prophase and in response to mechani
【机 构】
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IFOM (Fondazione Istituto FIRC di Oncologia Molecolare) Via Adamello 16,20139 Milan,Italy
【出 处】
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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern
论文部分内容阅读
The ATR pathway controls chromosome integrity and chromatin dynamics.We recently found that ATR, ATRIP and Chk1 associate to the nuclear envelope during S phase and prophase and in response to mechanical stimulation of the plasma membrane.The ATR-mediated mechanical response occurs within the range of physiological forces, recovers rapidly, and is not influenced by RPA or DNA damage.ATR defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown.
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